• Cognitive Support (Nootropic effects)
    • Traditionally used in Ayurveda to improve memory, learning, and concentration.
    • Mode of action: Increases acetylcholine levels in the brain by inhibiting acetylcholinesterase (AChE), supporting neurotransmission linked to memory and cognition.
    • Enhances hippocampal function and synaptic plasticity (shown in animal studies).

  • Neuroprotective & Anti-oxidant
    • Protects neurons from oxidative stress and chemical-induced neurotoxicity.
    • Mode of action: Rich in alkaloids and sesquiterpene esters that scavenge free radicals, reduce lipid peroxidation, and improve mitochondrial function.
    • May help prevent age-related cognitive decline and neurodegenerative conditions.

  • Mood & Stress Regulation
    • Traditional use for reducing anxiety and promoting calmness.
    • Mode of action: Modulates monoamine neurotransmitters (serotonin, dopamine) and reduces HPA-axis hyperactivity, contributing to anxiolytic and adaptogenic effects.

  • Anti-inflammatory & Analgesic
    • Traditionally applied in joint disorders, arthritis, and inflammation.
    • Mode of action: Seed oil reduces pro-inflammatory cytokines (e.g., TNF-α, IL-1β) and inhibits cyclooxygenase (COX) pathways, reducing pain and swelling.

  • Other Reported Uses
    • Aphrodisiac — improves libido and sexual vitality (possibly via hormonal and dopaminergic modulation).
    • Digestive support — used for gas, abdominal discomfort, and general digestive balance.

Celastrus paniculatus

Intellect tree

gray concrete wall inside building
gray concrete wall inside building
Medical Benefits
Usage

  • Stress / Anxiety / Mood
    • Lowers cortisol, modulates HPA-axis
    • May increase GABA and serotonin
    • Clinical trials show reduced perceived stress and anxiety

  • Hormonal / Vitality Effects
    • Increased testosterone and DHEA-S in overweight/aging males

  • Anti-Inflammatory / Antioxidant
    • Reduces inflammatory markers (TNF-α, IL-6)
    • Decreases oxidative stress (shown in animal & in vitro studies)

  • Cognitive / Sleep Support
    • Some studies report improved sleep quality, memory, and attention

  • Muscle Strength / Performance
    • RCTs show increased strength and muscle gains when combined with resistance training

  • Seed oil:
    • Traditionally: 10–20 drops/day in warm milk or water.
    • Modern extracts (standardized): doses vary, but often 200–300 mg/day in capsule form.

  • Seeds:
    • Ayurveda: 10–15 seeds chewed daily for cognitive benefits.
    • Not commonly used raw in modern practice due to variability in potency.

white and black abstract painting
white and black abstract painting

  • Cognition and neuroprotection:
    • Cognition-enhancing properties of Celastrus paniculatus seed oil in rats

  • Comprehensive phytochemical review:
    • Celastrus paniculatus in Ayurveda: a comprehensive review

  • Antioxidant & neuroprotective effects:
    • Neuroprotective and nootropic activity of Celastrus paniculatus seed oil

Reference

Daxina

Building Collaborations With;

Retailers;